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Prometazine with codeine is a combination of an antihistamine medication that relieves the allergy related symptoms including sneezing, runny nose, cough and itchy of the nasal/oral mucosa. Codeine is a narcotic drug with moderate antitussive (cough suppressant) properties that should be avoided in childrens (<6 years) due to a high risk of develop respiratory depression as with other narcotics. Never drink alcohol while taking Codeine. Its not recommended to take it for a longer period or in a higher dose than prescribed by your doctor. You should not use this medication if you have active asthma, COPD. Take codeine with food or milk if it upsets your stomach. Do not stop using codeine suddenly, or you could have unpleasant withdrawal symptoms. Get emergency medical help if you have twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; tremor (uncontrolled shaking), drooling, trouble swallowing, or problems with balance or walking.
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Questions, experiences and reviews (93)

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What is the difference between Promethazine VC w/ Codeine and Promethazine w/ Codeine?
I get pneumonia frequently and they usually give me Promethazine w/ Codeine 10-6.25 for my cough. This time they prescribed Promethazine VC w/ Codeine 10-5-6.25 instead. What is the difference and what does the "VC" mean?
Fireman 1
06/05/08
Reply
  VC stands for the addition of a decongestant- so you have promethazine which is an antihistamine and codeine an opiod all in one. Sounds like it may work for you. Be careful with driving until you get used to their effect. It may also affect your sleep patterns.
mistered1133
06/06/08
Does Promethazine or Codeine have any traces of cocaine in it?
Some dumbass white dude at my skool keeps trying to say Purple Drank/Purple Lean has cocaine in it. I'm tellin him that all Purple Drank is Sprite, and Promethazine/Codeine Cough Syrup. So basically the question is: does Promethazine or Codeine have any cocaine? I know Codeine is a narcotic, made from opium, so I dont think it has any cocaine in it.
Dynasty
04/02/08
Reply
  No. Cocaine is stimulant, and a completely different compound extracted from coca leaves. Codeine is an opiate, synthesized from morphine which in turn is synthesized from opium. Cocaine would definitely not be in a codeine mixture.
Fin
04/02/08
Question for someone whos been prescribed promethazine with codeine syrp recently?
I was always curious about promethazine with codeine syrup and i wanted to know what dosage it says on the bottle... Does it just say how to take it or the name, or does it show dosage wise! Just wonderin, thanks!
BlAzE-1
09/25/09
Reply
  the dosage is usually determined by a doc, & depending on his/her directions, it will say how to take it. It really works to get rid of a bad/resistant cough & a good night's sleep.
Sierra
09/25/09
with a really bad cough is there somewhere i can get promethazine with codeine w/o prescription?
where can i find promethazine w codeine plz help me out
Haze
01/31/10
Reply
  not without a prescription
JIM O
01/31/10
Lean, Promethazine, Codeine, Sizzurp... Heeelp?
What are the effects of Promethazine/codeine? Is there any bad side effects or any bad reactions you can get from it? I've had a bad past with weed, & have major panick attacks that last a while whenever i do smoke. So i completely quit. Alcohol doesnt have any bad effects on me. But i wanna try leaning, Anybody have any bad experiences ? Do you think i'll panic from it ?
Joe
12/06/11
Reply
Would taking Paxil, Morphine, and promethazine with codeine all at the same time kill?
I need to know right away, if there deadly or not. I just took all three together:
120mg of Morphine
About 5 Table Spoons of Promethazine w/Codeine
& 40mg of Paxil
hollywoodbopbaby
04/30/11
Reply
Possible overdose on Promethazine and Codeine cough syrup?
I got confused and took 2 Tablespoons of Promethazine with Codeine cough syrup instead of 2 teaspoons do i need to call poison control or will i be okay?
Ebf234
01/24/10
Reply
  You'll be fine. You might feel a little high though. Just lay down, drink lots of water.
Sex Addict
01/24/10
can you take Meloxicam with Promethazine w/ Codeine?
i was at the doctors Wednesday with just a sore throat. nothing major. so i got prescribed Meloxicam to reduce the swelling. The day after worse symptoms started kicking in. Just went back to the doctors today and he prescribed me the Z-pack and Promethazine w/ Codeine. I forgot to ask if i could take the Meloxicam with that, so can i?
Thanks.
Tyler Bryant
01/28/11
Reply
Whats the difference between Promethazine w/codeine and Promethazine DM? What does DM mean?
MoFace
01/13/10
Reply
  One has codeine and the other has dextromethrophen in it. They are both cough suppressents.
Roberta P
01/14/10
Where in the world can you buy Promethazine w/ Codeine Syrup without a prescription?
Where in the world can you buy Promethazine w/ Codeine Syrup without a prescription? I thought that you could in Canada but I'm not sure now, any ideas? Thanks.
sharkdogcat40
03/09/09
Reply
  I believe you can buy it in the U.S. without a prescription if you can find a pharmacy which sell eligible C-Vs over the counter. Most pharmacies do not participate.
Lea
03/10/09
how do i get a prescription for promethazine with codeine cough syrup?
i want to know what EXACTLY to say to my doctor to get promethazine with codeine cough syrup..and u think she could tell if i need it wen she looks at my throat?? well just tell me EXACTLY wat i need to say to get the prescription. thanks
yourdaddyclutz
01/18/11
Reply
  Why do you want this? Is it because you have a terrible cough or because you want the codein? Tell him/her the problem and the doctor will decide what you need. I'm guessing the doctor will NOT give you promethazine because that is for NAUSEA.
Anne D
01/18/11
what is the diffrence between Promethazine w/Codeine and Tussionex?
dose any one know the diffrence between Promethazine w/Codeine and Tussionex.....
stunt_20
02/15/08
Reply
  promethazine + codeine= promethazine w/ codeine
hydrocodone+chlorpheniramine=tussionex
perpetual_wallflower
02/15/08
What is the diffrence between Promethazine w/Codeine and Tussionex?
dose any one know the diffrence between Promethazine w/Codeine and Tussionex.....
stunt_20
02/15/08
Reply
  Tussionex is hydrocodone polistirex and chlorpheniramine polistirex. so it is the same type of thing a cough suppressant/pain killer and an antihistamine.
shithe_ad
02/15/08
What is the difference between Promethazine w/codeine and Tussionex?
Felix
03/19/08
Reply
  Promethazine uses codeine to suppress coughs.
Tussinex uses hydrocodone to suppress coughs/
Both are antihistamines & both can make you drowsy.
knicname
03/19/08
Where I can Buy PROMETHAZINE VC W/ CODEINE SYRUP without prescription?
jeremy_allen_04
06/26/06
Reply
  if you are in Fort Lauderdale Florida go the corner of Six trunk Blvd and NW 9Th Avenue
boy_jam_arch
06/26/06
Where to Buy PROMETHAZINE VC W/ CODEINE SYRUP without prescription?
jeremy_allen_04
03/29/06
Reply
  Anywhere outside the US Either Mexico or Canada. Have friends?? Take a trip or call someone and have them send it. I agree with you -- it is the BEST cough syrup there is. It is the only one I use. When I go to the Dr. Office I ask him to write it for 16oz so I don't need refills so often. The co-pay is the same as a normally prescribed 4oz bottle. Good luck, and stay healthy.
the BOSS
03/29/06
Where can you buy Promethazine w/Codeine VC?
Or something comparable .. do they carry it at like cvs or other pharmecys ? I don't have a prescription!!! and how much does it cost?
Mike Lebert
05/14/11
Reply
Is it safe to drink promethazine with codeine that is 6 months expired?
Wondering because I don't want to waste this prescription...
Mandy M
11/04/09
Reply
  Never recycle medications. If you don't need it any more, return it to the pharmacy for safe destruction. If you think you need more medication talk to your doctor. Do not self-medicate. It's not safe.
malica
11/04/09
Does all Phenergan (Promethazine) w/ Codeine cough syrup taste the same?
I have a respiratory infection and the Dr. prescribed Phenergan w/ Codeine for my cough. I usually get this prescribed and it has a sweet fruity taste but I went to a pharmacy closer to home this time and this one tastes very bitter. Why would it taste so different? Does it differ from store to store or did they screw up the prescription?
Fireman 1
11/28/07
Reply
  Some of the liquid medications come in different flavors. If you don't like it, you can always get it flavored. If you are getting the generic, different generic houses use different flavorings.
Lea
11/28/07
My Phenergan w/ Codeine cough syrup tastes like crap. Did they give me the wrong medicine?
I have a respiratory infection and the Dr prescribed Phenergan (Promethazine) w/ codeine for my cough. It's the same thing he always prescribes for me only this time it tastes very bitter. Usually it tastes very pleasant (fruity and sweet). However, the color is the same as it usually is; purple.

I went to a different pharmacy this time, one closer to home. I'm wondering if they screwed up the prescription and gave me something else instead...

What do you think?
Fireman 1
11/28/07
Reply
  Is this medicine mixed by the pharmacy? If it is, the original pharmacy probably adds that flavoring to cover the bad taste. The new pharmacy may not add this flavoring, so it ends up tasting pretty terrible.
counter774
11/28/07
Does anyone know of any drug stores that sell cough syrup with promethazine and codeine?
please.
I used to be able to get it pretty easily, but i moved and dont know anyone. What are the symptoms to whatever you need that medicine for?
brycee
12/24/07
Reply
  Almost any drug store has cough meds with codeine but because of all the drug abuse around the medication is kept behind the pharmacy counter. You have to sign for it and the pharmacist has the right to refuse to sell it to anyone.
impurrfect10
12/24/07
Promethazine?
Have you ever heard of someone abusing the drug Promethazine? I was wondering if it has side effects, as I think someone might have jacked my prescription. I got it for a surgery to help with nausea, and I was wondering why anybody would have a reason for stealing PROMETHAZINE?
Jillian
03/21/08
Reply
  One reason would be for the anti nausea it gives so if you were hungover. Promethazine is sometimes used as a recreational drug in conjunction with codeine in prescription cough syrup. The syrup by itself contains 7% alcohol. The mixture of Sprite and cough syrup with codeine, which is known as "purple drank" or "Sizzurp", is popularized in the rap world, especially in the Houston area.
rpghope18
03/21/08
Is there a way to get promethazine codeine with out any prescription?
I work all day and the cold weather has gotten the best of me, I have a terrible cough and I could use some much needed relief. Robitussin is ok but didn't really help all that much. Does anyone have any useful information on how I can purchase some online?
Mango
01/07/11
Reply
  No.

In The United States Phenergan with Codeine (promethazine/codeine) is a prescription medication and a Federally controlled schedule V substance due to its potential for abuse.

Buying it online is a crime although many web sites will say it is legal. You must get a prescription to obtain the medication.
Mathieu
01/07/11
How to roll a blunt with promethazine/codeine?
How do you suggest rolling a blunt with prom/cod syrup?
no surrenda
11/13/09
Reply
  Don't bother. Best to do them separately.
Chronic IL
11/13/09
What is the difference between promethazine with codein and promethazine with dextromorphan?
Will it kill me? We have the promethazine with dextromorphan will this still work for purple lean?
Bob B
04/25/08
Reply
  Dextromethorphan is a cough suppressant that is found in many over-the-counter cough medicines. Codine is a narcotic that is used as cough suppressant, pain reliever, and a hypnotic.

Promethazine is used mostly to prevent nausea. It is also used as part of preoperative sedation to prevent nausea from the other types of sedation used.

If you have both, I don't recommend using them BOTH at the same time. You may overdose.
darpunzel
04/25/08
I stopped taking promethazine VC W/ codeine syrup after 4 days. I can not fall asleep because my muscles twitc
The syrup was prescribed to cure coughing with fever
mamalove
04/04/06
Reply
  if you are having a negative reaction coming off the drug you probably should go see the prescribing doctor for a follow up.
netty5
04/04/06
What is the difference between Codeine Sulfate, Codeine, and Hydrocodone?
I have chronic cough and muscle stiffness and pain often. I have been prescribed everything from Tylenol 3 (30mg Codeine and Tylenol) to Hydrocodone 10mg/1000mg.

I've noticed that codeine seems quite weaker than Hydrocodone. If I take 2 hydrocodones, the same feeling takes 3-4 codeine tablets to acheive the desired feeling.

Recently, someone told me I should try Codeine Sulfate (60MG), they are small white tablets and contain no Tylenol, Asprin, or Ibuprofen. If I take 2 of these, will they be more similar to Hydrocodone or the Tylenol 3's?


What is the difference between Codeine Sulfate, Codeine, and Hydrocodone?
Repkying to first answer someone left.

Tylenol 3's and 4's are the combination of codeine with acetemetophin.

Hydrocodones (Vicodin, Lortab...etc) is the combination of Hydrocodone with acetemetophin.

Vicodin 5/500 is 5mg hydrocodone/500mg acetemetohin.

Tylenol 3's are 30mg Codeine / 300mg Acetemetophin.

Hydrocodone must be a different form of codeine that is stronger. MY main question is....What is the difference between Hydrocodone and Codeine? And where does codeine sulfate fit in the mix.

I do like your answer, it just lacks the main information I need.
annon1234
02/26/09
Reply
  I'm not familiar with codeine sulfate vs. codeine.

I know that hydrocodone is a combination of codeine plus an NSAID. I think it's acetaminophen.

Hydrocodone will be more powerful than codeine alone, because the 2 drugs combined provide a stronger effect than either would separately. You can get the same thing from taking codeine and tylenol pills separately, 10 mg and 1000mg respectively. It's the same thing.
Iori in Danger
02/26/09
can I take codeine promethazine with a fever? I have strep throat and its extremely painful?
advice please! thank you
I know it is strep because i went to the hospital and I was so sick they had to give me an IV and pump me full of antibiotics. I don't have any cough syrup but I was going to call my doctor and ask for some. You didnt even answer the question....
Thank you!
chilla
07/06/10
Reply
What does fiorinal with codeine feel like?
Can someone tell me what fiorinal and codeine feels like? I usually take vicodin when I get a severe migrain because thats the only thing that works!! I cant take topamox because it makes me forget and imitrex doesnt work! I have fiorinal without the codeine and it works ok but Ive heard that fiorinal with codeine is more effective!
Kim and Jim
08/06/08
Reply
  Vicodin has hydrocodone in it, and codeine in th fiorinal makes them both controlled substances. The hydrodocone is a stronger narcotic, but fiorinal is the med of choice for migraines, because of the compounded drugs and their action.
deb s
08/06/08
Can you mix acetaminophen with promethazine w/ codeine syrup safely?
I have a nasty bug right now, I need some relief. So I was wondering if i could mix Tylenol 500mg with this cough syrup i have from the last time i was sick safely without making some lethal drug combo.
VirusOfPity
04/03/09
Reply
  yes you can safely take the two together, just be sure not to repeat the dose any sooner than four hours. You must not take more than 4000 mg of tylenol in 24 hours, and the doses must be divided or you risk liver damage.
essentiallysolo
04/03/09

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