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Questions, experiences and reviews (12)

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If someone is diagnosed with Philadelphia chromosome and is taking gleevec without leukemia?
will leukemia still develop or will the gleevec fix the disorder
Steven P
01/09/10
Reply
  Gleevec treats leukemia patients (with CML) that are positive for the Ph chromosome specifically. Two things can happen to a CML patient taking Gleevec. The cancer can disappear completely for the rest of the patient's life, and the Ph chromosome becomes non-detectable even using advanced molecular techniques. This is called a molecular complete response. But more often, a few of the leukemic cells are resistant to the effects of Gleevec and they slowly take over and become the majority of cells. Then the patient has developed Gleevec resistant CML, and must choose a new therapy, such as Tasigna.
So to answer your question, sometimes Gleevec fixes the disorder and sometimes leukemia still develops. I'm sorry that this is probably not very satisfying. If the Ph-positive leukemic cells disappear from the bone marrow, this is a very positive prognostic factor.
Laurent
01/09/10
Who is the manufacturer/distributor of GLIVEC/GLEEVEC in the Philippines?
Adjuvant GLIVEC / GLEEVEC is a medication for cancer.
em
08/18/08
Reply
  There is only one manufacturer; Novartis.
They have an office in the Philippines.
2/F Asian Reinsurance Bldg.
Salcedo & Gamboa Streets
Legaspi Village, Makati City
RP-1229 Manila
Denisedds
08/21/08
Anyone taking Gleevec for awhile able to relate thier experience?
My wife is recently diagnosed with CML and will be taking gleevec it looks like maybe for years. It would be very helpfull if others could tell us how they have done since taking it: biggest side effects you have felt, time in remission. Any advice you would offer us?
Thank you
monkeyfun_16901
10/25/07
Reply
  You would probably find more answers to your questions on a message board or support group for CML. Try asking this question at the following site.

ACOR: CML Chronic Myelogenous Leukemia (Cancer) email group
http://listserv.acor.org/archives/cml.html

NCI: Questions and Answers about Gleevec
http://www.cancer.gov/newscenter/qandagleevec

CML Support
http://www.cmlsupport.com/

Imatinib (marketed as Gleevec), as you know, is a new type of treatment that targets proteins found in specific cancer tumors. This type of drug is different from the chemo that targets all cell growth and can kill both good and bad cells. The new type of cancer drugs are developed to target only that protein . .which means that there are fewer side effects. Besides Gleevec there are now whole families of this type of drug being tested on various cancers (Sunitinib, Dasatinib, Erlotinib, Gefitinib, Lapatinib, Nilotinib, Sorafenib)

The most common side effects are diarrhea, edema, nausea, rash, and possible loss of pigmentation (hair turns white).
Panda
10/25/07
Is there any relief from the chills associated with Dasatinib{Sprycell} or Imatinib{Gleevec}?
Currently Sprycell for 22 months. Cannot tolerate anymore. Previously same experience with Gleevec{24 months}
JakHamer
01/15/10
Reply
  Well, depending on your disease condition, you can talk to your henatologist/oncologist about lowering your dose. If you're doing pretty well as is, reducing your dose may not have a very, or even slightly, negative impact on your treatment. As you know, there's really only one other drug in the modern CML line up, so you want to try to hang on to each medication you're using as long as is feasible.
Z
01/16/10
What happens if you stop taking gleevec for a few months? ?
A family member had a GIST tumor (along with half his stomach and spleen) removed this summer. Now he's supposed to take Gleevec for 6-12 months; but he doesn't have insurance. If he doesn't take the drug for a few months, and then starts again will it be as effective? How will this affect his prognosis?
JENNIFER R
09/27/08
Reply
  An excellent online non profit online resource is Needy Meds which can point your family member to free or low cost programs for this type of medication:

http://www.needymeds.org/

Your relative should first check with the company that makes Gleevec to see what programs they have available and see if he qualifies:

http://www.needymeds.org/drug_list.taf?_function=name&name=Gleevec

He really should stay on the Gleevec and not go on and off it. Hopefully one of the programs will work for him.

Good luck.
Panda
09/27/08
Do you have to stay at the Mayo Clinic to take the stomach tumor drug Gleevec ?
I have read some of the other questions about stomach tumors and the use of Gleevec at the Mayo Clinic. Is this treatment inpatient or do you just take it during your normal daily routine? I just found out I have one that they say needs to be removed but I guess I have to have some kind of internal sonagram done to find out if it has blood vessels attached to it or not. It would be nice if you didn't have to wait so long to see if it is cancerous or not.
Kevin G
10/01/06
Reply
  Gleevac is an oral agent. It will be prescribed to you and you will take the pills as your doctor prescribes them.

Here is the link to the drug's website.

http://www.gleevec.com/index.jsp?usertrack.filter_applied=true&NovaId=2229644950363135312
Kristin C
10/01/06
Does anyone know how much the copay is for gleevec with humana?
evo741hpr3
03/17/09
Reply
  There's several different plans within Humana. Go to their website and set up an account. Go to the drug list and it will tell you the copay. I believe on most Humana plans, gleevec requires preauthorization.
april
03/17/09
If someone has the Philadelphia chromosome and they are being treated with Gleevec will the leukemia be gone?
Steven P
01/08/10
Reply
  Nope. Gleevec eventually stops working for most people who don't die of unrelated causes during treatment, and some patients discontinue using it before it stops working because of side effects.

It, along with tasigna and sprycel, offer much more effective treatment than the older generation of drugs, but they are by no means a cure.
Z
01/08/10
whats the life expectancy of a person with leukemia taking gleevec?
Sara B
04/11/07
Reply
  I don't think that has been determined yet. While the CML for some people develops resistance, many have not yet and may never. Even after failure with Gleevec, CML has several other treatment options like Sprycel and Tasigna. Finally, more traditional therapy options like interferon and hydroxea.

Targeted therapies (Gleevec, Sprycel and, Tasigna) have been quite successful at maintaining indefinite remissions in CML.
oncogenomics
04/11/07
Important Leukemia question?
Would someone the age of 17 be able to take medication
such as Tasigna, Sprycel, or Gleevec for CML? (Chronic Myeloid Leukemia)
Bethanne Lovesya
05/15/11
Reply
  Yes. Even younger people are put on medicines like that for CML and for other leukemias (sometimes Ph+ or MLL leukemias.)
TrueSnapdragon
05/16/11
I have CML and my WBC has gone from 41 to 82 in just a week. Is intervenous chemo be given at this time?
Sprycel is no longer working and I've already had Gleevec and interferon in which stopped working after a while. I have a lot of bone pain and I'm on medication for that, but I would like to consider IV Chemo and wonder if that is an option.
irish
01/11/08
Reply
  This does sound worrisome, Irish. It may be time for a bone marrow biopsy to find out what is going on.
SLC Mom
01/12/08
Can Gleevec help my sister who has stage 3 breast cancer that has now gone into bone cancer stage 4?
the cancer has spread thru out her body and she has a few spots on her liver, plz advise. thank you
Raquets
05/24/10
Reply
  It isn’t used to treat breast cancer or bone cancer, but she does not have bone cancer and any treatment for bone cancer would not help. Her oncologist has all the information needed to know how to treat her.
Denisedds
05/24/10

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virginiahughes: @celebritydx, I thought hitchens wrote recently that gleevec wouldnt work on his partic mutations? I think he explained in Vanity Fair...?